Individualised 177Lu-DOTATATE treatment of neuroendocrine tumours based on kidney dosimetry
نویسندگان
چکیده
منابع مشابه
Method dependence, observer variability and kidney volumes in radiation dosimetry of 177Lu-DOTATATE therapy in patients with neuroendocrine tumours
BACKGROUND Radionuclide therapy can be individualized by performing dosimetry. To determine absorbed organ doses in (177)Lu-DOTATATE therapy, three methods based on activity concentrations are currently in use: the small volume of interest (sVOI) method, and two methods based on large VOIs either on anatomical CT (aVOI) or on thresholds on functional images (tVOI). The main aim of the present w...
متن کامل1165TiPNETTER-1: FIRST PIVOTAL PHASE III STUDY EVALUATING 177LU-DOTATATE IN MIDGUT NEUROENDOCRINE TUMOURS.
1165TiP Citation: Annals of Oncology, Volume 25, Supplement 4, 2014 NETTER-1: FIRST PIVOTAL PHASE III STUDY EVALUATING 177LU-DOTATATE IN MIDGUT NEUROENDOCRINE TUMOURS M. Lopera Sierra, D. Kwekkeboom, M.F. Mariani, L. Bodei, P. Santoro, E.P. Krenning 1 Medical Affaires, Advanced Accelerator Applications, Saint Genis Pouilly, FRANCE 2 Nuclear Medicine, Erasmus University Medical Center, Rotterdam...
متن کاملNAMPT Inhibitor GMX1778 Enhances the Efficacy of 177Lu-DOTATATE Treatment of Neuroendocrine Tumors.
Neuroendocrine tumors (NETs) can be treated by peptide receptor radionuclide therapy using radiolabeled somatostatin analogs. However, the efficacy of such treatment is low and needs to be optimized. Our study evaluated the potential radiosensitizing effects of inhibition of nicotineamide phosphoribosyltransferase on 177Lu-DOTATATE treatment in a NET model. METHODS Nude mice xenografted with ...
متن کاملImproving quantitative dosimetry in 177Lu-DOTATATE SPECT by energy window-based scatter corrections
PURPOSE Patient-specific dosimetry of lutetium-177 ((177)Lu)-DOTATATE treatment in neuroendocrine tumours is important, because uptake differs across patients. Single photon emission computer tomography (SPECT)-based dosimetry requires a conversion factor between the obtained counts and the activity, which depends on the collimator type, the utilized energy windows and the applied scatter corre...
متن کاملEfficacy and safety of 90Y-DOTATATE therapy in neuroendocrine tumours.
BACKGROUND The aim of this study was to assess the efficacy and toxicity of peptide receptor radionuclide therapy (PRRT) with the use of the high affinity somatostatin receptor subtype 2 analogue, (90)Y labelled Tyr3-octreotate, ((90)Y-DOTATATE) in neuroendocrine tumours (NETs). MATERIAL AND METHODS 46 patients with disseminated or non-operable NET were enrolled in this study. The (90)Y-DOTAT...
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ژورنال
عنوان ژورنال: European Journal of Nuclear Medicine and Molecular Imaging
سال: 2017
ISSN: 1619-7070,1619-7089
DOI: 10.1007/s00259-017-3678-4